Histological Observation of the effects of Moringa Oleifera Leaf Extract on Lead Poisoning in the Epididymis of Wistar Rat Models

Research areas: Year: 2014
Type of Publication: Article Keywords: Epididymis Lead Moringa Effects Rat
  • Joshua O Owolabi JO, and Lynda N Nwobi Philip O Ogunnaike
Journal: Journal of Medical and Biological Sciences Volume: 4
Number: 2 Pages: 1 - 13
Month: December
Lead poisoning is a serious global environmental challenge especially due to the extensive deleterious effects that lead produces on body tissues as well as the overall compromising effects it has on the quality of life. While the world still seriously labour to prevent or minimise the occurrence of lead poising, there should also be research into how its effects can be neutralised, ameliorated or managed. Moringa oleifera is a natural product that has shown promises with respect to the amelioration of lead poisoning effects on various body issues on experimental studies’ reports. This investigation is an attempt to observe the possibility of moringa exhibiting a positive anti-lead toxicity effects on the histology of the tissue of the epididymis. Four groups of 6 Wistar rats were used. Group A served as control and as such were fed ad libitum; Group B received 200mg/kg body weight of moringa leaf extract to observe if there were effects produced by the extract; Group C received 50mg/kg body weight of lead in order to observe the sole effects of lead while Group D received concurrently moringa leaf extract and lead, being an attempt to observe whether moringa extract action against lead toxicity would produce positive effects. Experiment lasted 28 days. Animals’ tissues were obtained after sacrifice and processed using the haematoxylin and eosin staining. Moringa did not produce any marked effect against lead poisoning in the epididymis; on its own it also has a negative effect on the epididymis epithelium, especially the pseudostratified columnar cells.